Not much. Well, actually, some of them are a lot more expensive than others. Seriously though, the all have exactly the same ScriptOS operating system and are programmed using WinScript. The major difference is that they have different numbers of inputs, outputs and serial ports. As a point of interest, the IO64 and DMX Machine also should be included in this comparison. And they are! Check out:
http://www.alcorn.com/products/showcontrol/index.html
It's also worth noting that the outputs of some products, such as a V16, are more robust than other (an InterActivator, for example). For additional detail, see the Show Control User's Guide at
http://www.alcorn.com/library/manuals/index.html